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Orlistat (brand name Xenical) is a prescription drug that blocks about 30% of the fat you eat from being absorbed by your body. There's an over the counter version named Alli which has been available since June 2007.
Roche manufactures Orlistat and GlaxoSmithKline puts out Alli. They're also known as tetrahydrolipstatin. It's a saturated derivative of lipstatin. That's an inhibitor of pancreatic lipases.
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If you take Orlistat, you should also be on a low calorie diet and on an exercise program -- see your doctor for details.
Orlistat works by inhibiting gastric and pancreatic lipases. These are the enzymes that break down triglycerides in the intestine. When they're blocked, the triglycerides you eat not hydrolyzed into absorbable free fatty acids. Because they can't be absorbed, they're excreted. You take it three times a day, before meals.
Orlistat creates loose, oily stools, more frequent stools, gas and fecal incontinence, which means you better be very careful and ready to run into a nearby bathroom. These are described as side effects. However, they happen with every fat-blocker type of product. One used to be marketed through network marketing. And Oleo foods.
Any time you talk about blocking the absorption of dietary fat, you're talking about fitting yourself with adult diapers. Just in case.
The only way to avoid this is to eat a lot less fat, so that's the natural tendency of people on the medication. And when they eat less fat . . . do they lose weight because they're eating a lot less fat?
Maybe the medication is just a form of behavior modification?
In one year clinical trials, the patients taking Orlistat lost about 5% more weight than did the control group. If you're 100 pounds overweight, that's all of five extra pounds lost during an entire year of suffering through oil, loose stools and fearing "fecal incontinence."
Thanks to this, a group named Prescription Access Litigation (PAL) awarded its 2007 "Bitter Pill Award" to GlaxoSmithKline. Their comment: "With Allies Like This, Who Needs Enemas?"
As a side effect to this side effect, the body can no longer absorb fat-soluble vitamins such as E, A, D, K and beta-carotene. Therefore, Orlistat patients are advised to take a supplement of these at bedtime.
On June 4, 2009 Orlistat was on a list of drugs the Federal Food and Drug Administration (FDA) is watching for having a "Potential Signal of Serious Risk" of liver toxicity.

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